The Food and Drug Administration initially approved the drug Trimethoprim in combination with Sulphamethoxazole for instance: Bactrim and Septra way back during 1973 but the drug was approved as stand-alone only during the year 1980. Trimpex-Trimethoprim is the man made synthetic antibiotic or anti-bacterial drug that interferes with the production of Tetrahydrofolic Acid which is one of the chemicals necessary in order for bacteria and human cells for generating proteins. Trimpex-Trimethoprim reduces or slows down generation of Tetrahydrofolic Acid through reduction or minimizing the enzyme that is responsible for making Tetrahydrofolic Acid from the D-hydrofolic Acid.

Trimpex-Trimethoprim diminishes the bacterial enzyme more than the corresponding human enzymes hence this drug has minimal effect on the production of Tetrahydrofolic Acid by humans. The drug is found to be effective against many different bacteria. The recommended dose preparations are in tablet form of 100mg and 200mg as well as in solution form of 50mg per 5 mL. The medication is indicated for use in treating the bacterial infection of urinary tract, traveler’s diarrhoea, respiratory and middle ear infections and as combination drug either with Sulphamethoxazole or Dapsone it is used for preventing and treating the Pneumocystis infections.

The recommended dosage of Trimpex-Trimethoprim is 100mg every 12 hours or 200mg every 24 hours for 10 days. Like all other antibiotic drugs, the treatment course for this drug too should be completed even if the symptoms improve earlier during therapy. However, patients having kidney disease should take lower dosage as their kidneys may nor remove the drug completely from the body and levels of this drug may increase thereby leading to cause side effects.